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Thermosensors serve a number of very important functions in both prokaryotic and eukaryotic cells. They detect changes in environmental temperature triggering adaptive responses for survival. Our team investigates what is the essence of the mechanism of thermosensing. What properties distinguish sensor transmembrane segments from structural non-sensor transmembrane segments? Is there a common physical-chemical base determining how sensors detect physical changes? To address these questions, we combine theoretical biophysics, advanced chemical biology with molecular biology techniques, functional studies in vivo, and in vitro reconstitution of membrane sensors in liposomes. We also collaborate with international groups which are expert in molecular dynamics and biophysical techniques. Our interdisciplinary approaches have led to innovative concepts on mechanisms of sensing and signal transduction that we are now using for rational sensor design.

Laboratorio de Microbiología - Subsuelo Sala 9 - Facultad de Ciencias Bioquimicas y Farmaceuticas - Universidad Nacional de Rosario - Suipacha 531 - Argentina - +54 341 4353377